Approximately one-half of all infertility is caused by sperm abnormalities. Many sperm disorders are due to a chromosome abnormality such as aneuploidy or a structural chromosome abnormality.

Men carrying a balanced translocation chromosome are at risk of producing sperm with a structural chromosome abnormality.

Several studies have determined that approximately 3-8% of sperm from normal, fertile men are aneuploid and 27-74% of sperm from men with severe infertility are aneuploid.

Couples with infertility due to male factor, should consider chromosome analysis on the males sperm prior to IVF.